Evaluation of delayed puberty usually reveals elevation of gonadotropins, indicating that the pituitary is providing the signal for puberty but the gonads are failing to respond. The next steps of the evaluation usually include checking a karyotype and imaging of the pelvis.[15] The karyotype reveals XY chromosomes and the imaging demonstrates the presence of a uterus but no ovaries (the streak gonads are not usually seen by most imaging).

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The individual's gonads do not have two X chromosomes, so the breasts will derece develop and the uterus will hamiş grow and menstruate until estrogen is administered. This is often given transdermally.

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